Wednesday, August 25th 2021   14:00-14:15 OPENING OF THE CONFERENCE 14:00-14:05 Welcome by Toomas Asser, Rector, University of Tartu, Estonia 14:05-14:15 Andres Metspalu, Chairman of the Board, Estonian Genome Foundation, Estonia “20 years of Gene Forum conference in Estonia: what has changed?” 14:15-16:45 GENOMICS FOR HEALTHCARE Moderator Mait Metspalu Keynote Professor Sir Peter Donnelly, Genomics PLC, UK „The potential for genomics to empower a new, prevention-first agenda for healthcare“ Professor Samuli Ripatti, University of Helsinki, Finland “The role of genomic information in common disease prevention“ Professor Gert Matthijs, KU Leuven, Belgium "Genomics in clinical diagnostics: guidelines and practice" Professor Cathryn Lewis, King's College London, UK "Polygenic risk scores for psychiatric disorders" Thursday, August 26th 2021   10:15-12:00 COVID 19 SESSION Moderator Pärt Peterson Professor Andres Merits, Institute of Technology, University of Tartu, Estonia “Does complex structure of RNA genome impose restrictions for natural variation and evolution speed of SARS-CoV-2?” Professor Adrian Hayday, Francis Crick Institute and King’s College, UK "Learning immunology from COVID-19" Dr. Andrea Ganna, University of Helsinki,Finland/Harvard Medical School, USA/Massachusetts General Hospital,USA, “The covid-19 host genetics initiative.” 12:00-14:00 Lunch Break 14:00-15:30 PHARMACOGENOMICS Moderator Lili Milani Dr. Charity Nofziger, PharmGenetix GmbH, Austria “Solving the CYP2D6 Incidentalome” Professor Ewan Pearson, University of Dundee, Scotland, "Genes, Drugs and Diabetes" Dr. Jesse Swen, LUMC, Netherland “Challenges and opportunities for pre-emptive pharmacogenetic testing“ 15:30-15:45 Break 15:45-16:45 MICROBIOME AND HEALTH Moderator Elin Org Dr. Michael Zimmermann, European Molecular Biology Laboratory, Germany “Identifying gut microbiome contributions to drug metabolism and toxicity” Dr. Jingyuan Fu, University of Gröningen, Netherland “From genome-wide association analysis to metagenome-wide association” 16:45-17:15 Professor Arne Merilai, Institute of Cultural Research, University of Tartu, Estonia “Poetics in Genes” Friday, August 27th 2021   10:00-11:30 GENE REGULATION AND IMMUNOLOGY Moderators Kaur Alasoo and Ana Rebane Dr. Judith Zaugg, European Molecular Biology Laboratory, Germany „Gene Regulation and Systems Epigenetics as Tools to Study Disease Mechanisms” Dr. Urmo Võsa, University of Tartu, Estonia “Leveraging large-scale eQTL mapping meta-analyses to prioritize trait-relevant genes in blood” Dr. Shai Shen-Orr, Technion - Israel Institute of Technology, Israel „Human immune monitoring coming of age“ 11:30-11:45 Break 11:45-12:45 Dr. Tilman Sanchez-Elsner, University of Southampton, UK „The LPS-induction of protein expression in monocytic cells is associated to mRNA binding to ribosomes, RNA sequence features and microRNA targeting“ Dr. Richard Oram, University of Exeter, UK "Can we predict the future? Improved classification and prediction of type 1 diabetes and celiac disease with polygenic scores" 12:45-13:15 POPULATION GENOMICS Dr. Matteo Fumagalli, Imperial College London, UK “Deep learning in population genomics: can AI solve the unsolvable?” 13:15-13:30 CLOSING REMARKS