Friday, August 30th 2019   08:40-09:00 Registration 09:00 OPENING OF THE CONFERENCE Welcome by Prof. Andres Metspalu, Estonian Genome Foundation/University of Tartu, Estonia Kristjan Vassil, Vice-Rector of Research, University of Tartu, Estonia Toomas Asser, Rector, University of Tartu, Estonia 09:10-10:30 OPENING SESSION (Chair: Prof. Andres Metspalu, University of Tartu) Keynote Prof. Dan Roden, Vanderbilt University Medical Center, USA "“Using large biobanks to advance an agenda for personalized medicine” " Prof. Heidi Rehm, Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA/ The Broad Institute of Harvard and MIT, Cambridge, MA, USA ""Supporting Genomics in the Practice of Medicine"" 10:30-10:50 Coffee / tea 10:50-12:45 SESSION I Moving towards personal medicine (Chair: Prof. Lili Milani, University of Tartu) Dr. Mathew Garnett, Wellcome Sanger Institute, UK "“Functional genomics approaches to identify targetable dependencies in cancer cells”" Prof. Ole Andreassen, University of Oslo, Institute of Clinical Medicine, Norway "“Predicting age of onset of complex diseases - precision medicine with clinical relevance”" Prof. Stefan Fröhling, Division of Translational Medical Oncology, German Cancer Research Center (DKFZ) Heidelberg, Germany ""Cross-Institutional Implementation of Comprehensive Genomic Analysis for Precision Oncology"" 12:45-13:55 Lunch 13:55-15:50 SESSION II Pharmacogenomics in personalized medicine (Chair: Dr. Tõnu Esko, University of Tartu) Prof. Henk-Jan Guchelaar, Leiden University Medical Center, The Netherlands ""The time for personalized medicine is now"" Prof. Lili Milani, Estonian Genome Center, Institute of Genomics, University of Tartu, Estonia ""Pharmacogenetic studies in the Estonian Biobank"" Prof. Erik Eliasson, Karolinska Institutet, Karolinska University Hospital Huddinge, Stockholm, Sweden "“Clinical uptake of pharmacogenetics at Karolinska”" 15:50-16:10 Coffee / tea 16:10-16:50 PANEL DISCUSSION “Genomics – Towards Improving Medicine” (moderated by Prof. Andres Metspalu) 16:50-18:00 SESSION III Epigenetics and gene regulation (Chair: Prof. Pärt Peterson, University of Tartu) Dr. Kerrin Small, King’s College London, UK ""Regulation of gene expression across tissues, time and environment"" Dr. Vardhman Rakyan, Blizard Institute, University of London, UK ""Mammalian ribosomal DNA as a molecular environmental sensor"" 20:00 Buffet Dinner (served at the Dorpat Conference Center) Saturday, August 31st 2019   09:30-11:30 SESSION IV Host-Microbiome interactions (Chair: Dr. Elin Org, University of Tartu) Prof. Peer Bork, EMBL, Heidelberg, Germany ""Tracing the invisible life in us and on the planet: The world of microbes"" Prof. Alexandra Zhernakova, University of Groningen, The Netherlands "“The gut microbiome: interaction of genetics, environment, and diseases”" Prof. Harri Alenius, Karolinska Institute, Sweden "“Molecular basis for allergy development: Impact of the living environment on microbe-host interaction in immune homeostasis and its dysregulation”" 11:30-11:50 Coffee / tea 11:50-13:50 SESSION V Evolutionary aspects of genetic traits (Chair: Dr. Mait Metspalu, University of Tartu) Prof. Iain Mathieson, University of Pennsylvania, USA ""Polygenic scores for complex traits across time and populations"" Prof. Lluis Quintana-Murci, Institut Pasteur, Paris, France ""Unraveling the sources of diversity of immune response phenotypes through population immunology studies”" Dr. Carina Schlebusch, Evolutionary Biology Centre, Uppsala University, Sweden ""The genetic history of Africa based on modern and ancient DNA"" 13:50-15:00 Lunch 15:00-16:50 SESSION VI Complex interactions in metabolic diseases (Chair: Dr. Ana Rebane, University of Tartu) Prof. Margit Mahlapuu, University of Gothenburg, Sweden "“STK25 -a Critical Determinant in Non-Alcoholic Fatty Liver Disease”" Prof. Frode Norheim, Faculty of Medicine, University of Oslo, Norway ""Gene-by-sex and gene-by-diet interactions in obesity"" Dr. Gregory Michelotti, Metabolon Inc., USA "“Metabolomics enhances understanding of genomic and metagenomic variation to provide novel insights into human health”" 16:50 Closing of the conference